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October 1, 1978Journal of VirologyOpen Access

Two initiation sites for translation of poliovirus RNA in vitro: comparison of LSc and Mahoney strains

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Population

In vitro translation system using poliovirus type 1 RNA (LSc and Mahoney strains)

Comparison

LSc strain of poliovirus type 1 RNA vs Mahoney strain of poliovirus type 1 RNA

Design

Preclinical

Authors

HJHolly G. JenseUniversity of UtahFKF KnauertUniversity of UtahEEE EhrenfeldUniversity of Geneva

Discussion

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Implication

Dual initiation sites in poliovirus translation are supported in vitro; leaves open in vivo relevance and magnesium effects on replication.

Structured PICO

P
Population
In vitro translation system using poliovirus type 1 RNA (LSc and Mahoney strains)
I
Intervention
LSc strain of poliovirus type 1 RNA
C
Comparator
Mahoney strain of poliovirus type 1 RNA
O
Outcome
Initiation sites for translation (incorporation of formyl-[35S]methionine into amino terminus of newly synthesized polypeptides)

Both LSc and Mahoney strains of poliovirus type 1 utilize two unique sites for the initiation of translation in vitro, with varying proportions depending on magnesium concentration.

Cite This Study

Jense et al. (1978) studied this question.

synapsesocial.com/papers/6a82573faedbb2834ec6ae33https://doi.org/10.1128/jvi.28.1.387-394.1978
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relations Between Poliovirus Polypeptides as shown by Tryptic Peptide Analysis1975 · 15 citations
  2. 2Thermosensitive Block of the Sabin Strain of Poliovirus Type I1972 · 26 citations
  3. 3The Initiation of Protein Synthesis Directed by the RNA from Encephalomyocarditis Virus1973 · 85 citations
  4. 4Complete translation of poliovirus RNA in a eukaryotic cell-free system.1975 · 90 citations
  5. 5Poliovirus-induced inhibition of polypeptide initiation in vitro on native polyribosomes.1976 · 69 citations