October 1, 1979Journal of General Virology

Possible Point Mutation Sites in LSc, 2ab Poliovirus RNA and a Protein Covalently Linked to the 5'-terminus

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Population

Poliovirus type I, vaccine strain (LSc, 2ab) grown in HeLa cells

Design

Preclinical

Authors

ANAkio NomotoTokyo Medical and Dental University SKSachiko KajigayaNational Institutes of Health KSKenta SuzukiYakut Scientific Research Institute of Agriculture

Discussion

Member takes

Implication

Hypothesis-generating in an animal model; leaves open relevance to human poliovirus pathogenesis or vaccine strategies.

Structured PICO

Population

Poliovirus type I, vaccine strain (LSc, 2ab) grown in HeLa cells

Intervention

Analysis of RNase T1 digests and proteinase K digests

Outcome

Identification of point mutation sites and 5'-terminus covalently linked proteinsurrogate

The study identifies possible point mutation sites on the genome of the LSc, 2ab mutant strain of type I poliovirus and confirms that a VPg protein is covalently bound to the 5'-terminus of its RNA.

Cite This Study

Nomoto et al. (1979) studied this question.

synapsesocial.com/papers/6a8af604e0eb9e4bd4f4446a https://doi.org/10.1099/0022-1317-45-1-107

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Possible Point Mutation Sites in LSc, 2ab Poliovirus RNA and a Protein Covalently Linked to the 5'-terminus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Possible Point Mutation Sites in LSc, 2ab Poliovirus RNA and a Protein Covalently Linked to the 5'-terminus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider