Poliovirus infection specifically stimulates the phosphorylation of certain polysome-associated proteins, which may serve a regulatory function during protein synthesis.
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May regulate polysome function during poliovirus infection; leaves open relevance to human cells or antiviral strategies.
In vivo phosphorylation of proteins that are associated with polysomes of poliovirus-infected VERO (African green monkey kidney) and HeLa (Henrietta Lacks) cells differed from phosphorylations observed with uninfected cells that were fed fresh medium. With both types of cells infection stimulated phosphorylation of proteins with molecular weights of 40 000-41 000, 39 000, 34 000, 32 000, and 24 000. Similarities of phosphorylations in VERO and HeLa cells suggest that they are a specific consequence of infection and might serve a regulatory function during protein synthesis.
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James et al. (1981) studied this question.
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