April 1, 2015British Journal of PharmacologyOpen Access

Effects of chronic treatment with the new ultra‐long‐acting β₂‐adrenoceptor agonist indacaterol alone or in combination with the β₁‐adrenoceptor blocker metoprolol on cardiac remodelling

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Why the study?

Does indacaterol alone or in combination with metoprolol improve cardiac remodelling in a rat model of heart failure?

Structured PICO

Does indacaterol alone or in combination with metoprolol improve cardiac remodelling in a rat model of heart failure?

Population

Rat model of heart failure (myocardial infarction)

Intervention

Indacaterol 0.3 mg·kg(-1)·day(-1) alone or in combination with metoprolol 100 mg·kg(-1)·day(-1) for 15 weeks

Comparator

Untreated heart failure rats and sham-operated rats

Outcome

Myocardial histology (infarct size), haemodynamic parameters (blood pressure, heart rate, ejection fraction), and markers of remodelling (left ventricular internal diameters, β1 adrenoceptor mRNA expression, cardiac cAMP levels, GPCR kinase 2 expression)surrogate

The combination of indacaterol and metoprolol showed additive benefits in reversing cardiac remodelling in a rat model of heart failure, suggesting potential therapeutic utility for patients with concurrent heart failure and COPD.

Discussion

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Implication

May support combined indacaterol-metoprolol therapy in experimental HF; hypothesis-generating for comorbid COPD and requires clinical validation.

Cite This Study

Rinaldi et al. (2015) studied this question.

synapsesocial.com/papers/6a82617d720902ef117956ec https://doi.org/10.1111/bph.13148

Topics

Heart failure HFrEF treatment

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Implication

May support combined indacaterol-metoprolol therapy in experimental HF; hypothesis-generating for comorbid COPD and requires clinical validation.

Effects of chronic treatment with the new ultra‐long‐acting β₂‐adrenoceptor agonist indacaterol alone or in combination with the β₁‐adrenoceptor blocker metoprolol on cardiac remodelling

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effects of chronic treatment with the new ultra‐long‐acting β₂‐adrenoceptor agonist indacaterol alone or in combination with the β₁‐adrenoceptor blocker metoprolol on cardiac remodelling

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider