Why the study?
Does loss of function in RGS6 alter intrinsic heart rate variability and increase susceptibility to atrial fibrillation?
Population
Isolated heart preparations, single-cell recordings of sinoatrial cardiomyocytes, Rgs6 knockout mice, and…
Comparison
Ablation of Rgs6 or loss of function variants in… vs Wild-type mice and humans without RGS6 variants
Design
Preclinical
Authors
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RGS6 loss may heighten AF susceptibility; hypothesis-generating for human rhythm disorders.
Does loss of function in RGS6 alter intrinsic heart rate variability and increase susceptibility to atrial fibrillation?
The m2R-I(KACh) signaling pathway and its regulator RGS6 play an essential role in controlling intrinsic heart rate variability and may be implicated in arrhythmia pathogenesis.
Posokhova et al. (2013) studied this question.
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