Population
Human brain tissue, Chinese hamster ovary (CHO) cells, and human embryonic kidney (HEK293T) cells
Comparison
Cloning and expression of human type III… vs Human type II voltage-gated sodium channel
Design
Preclinical
Authors
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May alter neuronal excitability via persistent currents; animal data leaves open roles in human brain physiology and disease.
The distinct biophysical properties and wide distribution of the human type III sodium channel in the adult brain suggest it may have important physiological and pathological roles.
Chen et al. (2000) studied this question.
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