Why the study?
Does captopril alter the pressor response to exogenous angiotensin II, vasopressin, and norepinephrine in normal female Wistar rats?
Does captopril alter the pressor response to exogenous angiotensin II, vasopressin, and norepinephrine in normal female Wistar rats?
Chronic ACE inhibition with captopril blunts the pressor response to norepinephrine while enhancing responses to angiotensin II and vasopressin, suggesting inhibition of sympathetic activity contributes to its antihypertensive efficacy.
No takes yet. Share an insight, caveat, or question.
Does not inform pressor dosing during ACE inhibition; leaves open sympathetic blunting as antihypertensive mechanism in humans.
Spertini et al. (1981) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: