Why the study?
Does inhibition of contractile activity with TTX alter the biogenesis of sarcoplasmic-reticulum Ca(2+)-ATPase in cultured embryonic-chick skeletal-muscle fibres?
Does inhibition of contractile activity with TTX alter the biogenesis of sarcoplasmic-reticulum Ca(2+)-ATPase in cultured embryonic-chick skeletal-muscle fibres?
The biogenesis and accumulation of the sarcoplasmic-reticulum Ca(2+)-ATPase in skeletal muscle is regulated by contractile activity, with inhibition leading to increased protein turnover.
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Contractile activity may regulate SERCA turnover in avian skeletal myotubes; leaves open relevance to cardiac muscle or clinical translation.
Charuk et al. (1992) studied this question.
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