Mild obesity does not affect the forearm muscle microvascular responses to hyperglycemia

INTRODUCTION: Mild obesity has been associated with postprandial brachial artery vascular dysfunction. However, direct assessment of these effects within the forearm skeletal muscle microcirculation remains unclear. Thus, this study aimed to investigate the effects of mild obesity on the arm micro- and macrovascular responses to glucose ingestion. METHODS: This cross-sectional study combined NIRS assessments of forearm skeletal muscle (FDS) reactivity (reperfusion slope) with %FMD of conduit artery function (brachial artery) before (Pre), as well as 60 and 120 min after glucose ingestion in 10 lean (BMI 23.9 ± 1.8) and 10 obese (BMI 32.9 ± 1.9) individuals. RESULTS: Both groups showed a significant increase in the reperfusion slope at 60 and 120 min after glucose ingestion compared with the pre-glucose ingestion measurements. Obese individuals showed a significant (p < .05) reduction in %FMD at 60 min after glucose ingestion, while no significant changes in postprandial %FMD were observed in lean participants. CONCLUSION: Even though obese individuals showed impaired postprandial brachial artery function, the current findings suggest that mild obesity does not affect the forearm skeletal muscle responses to glucose ingestion.