Why the study?
Does valsartan 160 mg added to amlodipine 5 mg improve blood pressure reduction compared to losartan 100 mg added to amlodipine 5 mg in hypertensive patients inadequately controlled by amlodipine?
Population
221 hypertensive patients with inadequately controlled BP after 4 weeks of treatment with amlodipine 5 mg
Comparison
Valsartan 160 mg added to amlodipine 5 mg for 4… vs Losartan 100 mg added to amlodipine 5 mg for 4…
Design
RCT, randomized in a cross-over study design
Follow-up
4 weeks per treatment period
Authors
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Supports preferring valsartan/amlodipine for add-on therapy; extends randomized ARB comparisons in hypertension.
Does valsartan 160 mg added to amlodipine 5 mg improve blood pressure reduction compared to losartan 100 mg added to amlodipine 5 mg in hypertensive patients inadequately controlled by amlodipine?
Adding valsartan 160 mg to amlodipine 5 mg provides superior blood pressure reduction compared to adding losartan 100 mg in patients with inadequately controlled hypertension.
Roberto Fogari (2010) studied this question.
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