June 1, 1979Acta Anaesthesiologica Scandinavica
Epidural Analgesia Inhibits the Renin and Aldosterone Response to Surgery
Why the study?
Does epidural analgesia inhibit the renin and aldosterone response to surgery in patients undergoing hysterectomy compared to general anaesthesia?
Population
12 patients undergoing hysterectomy
Comparison
Epidural analgesia (extending from T4 to S5) vs General anaesthesia
Design
Cohort
Follow-up
24 hours
Authors
Discussion
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Member takes
Implication
Caution against practice change from hormone effects in hysterectomy; hypothesis-generating for non-mineralocorticoid sodium retention mechanisms.
Structured PICO
Does epidural analgesia inhibit the renin and aldosterone response to surgery in patients undergoing hysterectomy compared to general anaesthesia?
P
Population
12 patients undergoing hysterectomy
I
Intervention
Epidural analgesia (extending from T4 to S5)
C
Comparator
General anaesthesia
O
Outcome
Plasma renin activity, plasma aldosterone concentration, and urinary excretion of sodium and potassium over 24 hourssurrogate
Epidural analgesia blunts the renin-aldosterone response to surgical stress, indicating that post-operative sodium retention is mediated by non-mineralocorticoid factors.
Cite This Study
Brandt et al. (1979) studied this question.