Why the study?
Does thoracic epidural anesthesia prevent renin release in response to induced arterial hypotension in awake non-sedated patients?
Population
10 awake non-sedated patients
Comparison
Thoracic epidural anesthesia during a… vs Hypotensive challenge induced by sodium…
Design
Other
Authors
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Supports sympathetic mediation of renin release; leaves open whether epidural anesthesia affects outcomes during perioperative hypotension.
Does thoracic epidural anesthesia prevent renin release in response to induced arterial hypotension in awake non-sedated patients?
Thoracic epidural anesthesia suppresses renin release during induced hypotension, demonstrating the critical role of renal sympathetic fibers in mediating renin release in humans.
Hopf et al. (1994) studied this question.
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