Population
hERG-expressing human embryonic kidney (HEK) cells and neonatal rat cardiomyocytes
Design
Preclinical
Authors
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Provides a mechanistic basis for hypoxia-induced arrhythmias; leaves open whether targeting calpain degradation of.
Hypoxia reduces mature hERG channels through calpain up-regulation, providing a potential mechanism for hypoxia-associated cardiac arrhythmias.
Lamothe et al. (2017) studied this question.
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