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January 25, 2021EBioMedicineOpen Access

Renal interstitial fibroblasts coproduce erythropoietin and renin under anaemic conditions

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Why the study?

The physiological response to blood pressure changes under anaemic conditions remained unknown.

Population

Human patients and mouse and rat models

Authors

KMKenichiro MiyauchiTNTaku NakaiSSSakae Saito

Discussion

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Overview

Should not yet change anaemia management in CKD; leaves open a fibroblast renin-EPO axis in human fibrotic kidneys.

Structured PICO

P
Population
Human patients and mouse/rat models with anaemia and injured fibrotic kidneys
I
Intervention
Anaemic conditions and antihypertensive agents
O
Outcome
Expression of renin and erythropoietin in renal interstitial fibroblastssurrogate

Renal interstitial fibroblasts function as central controllers of systemic oxygen delivery and blood pressure by coproducing renin and erythropoietin under anaemic conditions.

Cite This Study

Miyauchi et al. (2021) studied this question.

synapsesocial.com/papers/6a82b4e3abc87fc4bf1e18f2https://doi.org/10.1016/j.ebiom.2021.103209
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Also Consider

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  1. 1Pericytes synthesize renin2013 · 39 citations
  2. 2Homeostatic Response of Mouse renin Gene Transcription in a Hypertensive Environment Is Mediated by a Novel 5′ Enhancer2018 · 2 citations
  3. 3Pathophysiology of anaemia: focus on the heart and blood vessels2000 · 376 citations
  4. 4Plasma renin in mice with one or two renin genes2004 · 27 citations
  5. 5Role of complement 3 in renin generation during the differentiation of mesenchymal stem cells to smooth muscle cells2020 · 15 citations