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January 22, 2018Molecular and Cellular BiologyOpen Access

Homeostatic Response of Mouse renin Gene Transcription in a Hypertensive Environment Is Mediated by a Novel 5′ Enhancer

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Population

Mice with deleted 5' (17-kb) or 3' (78-kb) regions of the endogenous mRen gene, and As4.1 cells

Comparison

Deletion of specific regions of the mRen gene… vs Mice with intact mRen gene regions (implied)

Design

Preclinical

Authors

AUAki UshikiHMHitomi MatsuzakiAFAkiyoshi Fukamizu

Discussion

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Overview

No immediate clinical implications; leaves open whether the mRen enhancer is a viable target for human hypertension therapies.

Structured PICO

P
Population
Mice with deleted 5' (17-kb) or 3' (78-kb) regions of the endogenous mRen gene, and As4.1 cells
I
Intervention
Deletion of specific regions of the mRen gene (5' 17-kb, 3' 78-kb, or 2.3-kb core enhancer) and exposure to a hypertensive environment
C
Comparator
Mice with intact mRen gene regions (implied)
O
Outcome
mRen gene transcription/expression responsiveness to hypertensionsurrogate

A novel 5' enhancer containing a 2.3-kb core sequence is essential for the homeostatic suppression of mouse renin gene transcription in a hypertensive environment.

Cite This Study

Ushiki et al. (2018) studied this question.

synapsesocial.com/papers/6a89286d9f05dd9930a2c142https://doi.org/10.1128/mcb.00566-17
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Appropriate Regulation of Human Renin Gene Expression and Secretion in 45-kb Human Renin Transgenic Mice1998 · 22 citations
  2. 2Critical Roles of a Cyclic AMP Responsive Element and an E-box in Regulation of Mouse Renin Gene Expression2001 · 134 citations
  3. 3Angiotensinogen-deficient mice with hypotension.1994 · 379 citations
  4. 4Ensembl 20162015 · 1,370 citations
  5. 5Role of Proximal Promoter Elements in Regulation of Renin Gene Transcription1996 · 116 citations