Why the study?
Does nicardipine IV bolus acutely decrease arterial blood pressure in anesthetized adult cardiac surgical patients?
Population
40 adult cardiac surgical patients under general anesthesia
Comparison
Nicardipine 0.25 mg, 0.50 mg, 1.00 mg, and 2.00… vs Self-controlled (dose-ranging)
Design
RCT, randomized, double-blind
Follow-up
acute (minutes)
Authors
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Enables rapid, titratable BP control without HR effects in cardiac anesthesia; extends pharmacokinetic data to anesthetized surgical patients.
Does nicardipine IV bolus acutely decrease arterial blood pressure in anesthetized adult cardiac surgical patients?
Nicardipine IV bolus effectively and rapidly decreases arterial blood pressure in cardiac surgical patients without affecting heart rate or cardiac output, though it may have a small negative inotropic effect.
Cheung et al. (1999) studied this question.
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