Why the study?
Does nicardipine IV bolus acutely decrease arterial blood pressure and affect left ventricular function in anesthetized adult cardiac surgical patients?
Population
40 adult cardiac surgical patients under general anesthesia
Comparison
Nicardipine IV bolus vs Self-controlled (baseline and different doses)
Design
RCT, randomized, double-blind
Follow-up
Acute (minutes)
Authors
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Enables rapid, titratable BP control in cardiac anesthesia without reflex tachycardia; extends RCT data to anesthetized surgical patients.
Does nicardipine IV bolus acutely decrease arterial blood pressure and affect left ventricular function in anesthetized adult cardiac surgical patients?
Nicardipine IV bolus effectively and rapidly decreases arterial blood pressure in cardiac surgical patients without affecting heart rate or cardiac output, though it may have a small negative inotropic effect.
Cheung et al. (1999) studied this question.
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