Why the study?
Does varying citrate concentration affect the prothrombin time test in normal subjects and patients on oral anticoagulants?
Population
12 normal subjects and 46 patients on oral anticoagulants
Comparison
Four concentrations of trisodium citrate… vs Comparison across the different citrate…
Design
Other
Authors
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Variable citrate concentrations may alter PT results; leaves open optimal uniform standardization for reliable anticoagulation monitoring.
Does varying citrate concentration affect the prothrombin time test in normal subjects and patients on oral anticoagulants?
The study demonstrates that varying citrate concentrations affect prothrombin time results, leading to the recommendation of a uniform 3.2% trisodium citrate (0.109 M) concentration.
Ingram et al. (1976) studied this question.
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