Why the study?
Are platelet cytosolic free calcium, serotonin concentration, and blood viscosity different between hypertensive and normotensive subjects?
Are platelet cytosolic free calcium, serotonin concentration, and blood viscosity different between hypertensive and normotensive subjects?
Hypertension is associated with increased platelet intracellular calcium, decreased serotonin, and altered hemorheological properties, which may contribute to its pathophysiology.
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Hypertension-linked platelet calcium rise and serotonin drop should not change practice; leaves open their mechanistic or therapeutic relevance.
In this study, the platelet intracellular calcium and serotonin (5-HT) concentrations as well as the hemorheological properties were compared in 65 hypertensive (HT) and 25 age-matched normotensive (NT) subjects. The result showed that the platelet intracellular calcium concentration in the HT group was significantly higher than in the NT group (165.4 +/- 12.6 vs. 118.9 +/- 12.4 nM, p < 0.05). However, the platelet 5-HT content in the HT group was significantly lower than in the NT group (0.28 +2- 0.03 vs. 0.38 +/- 0.03 nmol/10(8) platelets, p < 0.05). Moreover, red cell flexibility, red cell deformability, hematocrit, fibrinogen concentration and plasma viscosity were all significantly increased in HT subjects. The whole blood viscosity was generally higher in the HT group. In conclusion, the higher platelet intracellular calcium and lower 5-HT level as well as abnormality of hemorheological properties may be important factors in the initiation and perpetuation of hypertension.
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Ding et al. (2008) studied this question.
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