December 1, 1997Circulation Research

Venous Myogenic Tone and Its Regulation Through K+Channels Depends on Chronic Intravascular Pressure

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Population

Human saphenous veins and cephalic veins, and rat saphenous veins

Comparison

In vitro exposure to varying intraluminal… vs Human cephalic veins vs saphenous veins; rat…

Design

Preclinical

Follow-up

2 weeks (for rat model)

Authors

MSM SzentiványiJahn Ferenc Dél-Pesti Kórház és Rendelőintézet VBViktor BércziSemmelweis University THTivadar HüttlSemmelweis University

Discussion

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Implication

Human-rat saphenous vein K+ channel differences limit rodent model translation; leaves open species-specific mechanisms for venous graft research.

Structured PICO

Population

Human saphenous veins (SV) and cephalic veins (CV), and rat saphenous veins (experimental model of increased venous pressure via head-up tilt for 2 weeks)

Intervention

In vitro exposure to varying intraluminal pressures (2 to 30 mm Hg) and K+ channel antagonists (tetraethylammonium [TEA], iberiotoxin, 4-aminopyridine)

Comparator

Human cephalic veins (low in vivo pressure) vs saphenous veins (high in vivo pressure); rat saphenous veins with vs without 2 weeks of head-up tilt

Outcome

Level of myogenic tone and vein diameter changessurrogate

Increased venous myogenic tone correlates with higher chronic intraluminal pressure loads, and KCa and KV channels counterregulate this tone in human, but not rat, saphenous veins.

Cite This Study

Szentiványi et al. (1997) studied this question.

synapsesocial.com/papers/6a82c563d88fdfcf4fa0cb8f https://doi.org/10.1161/01.res.81.6.988

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Implication

Human-rat saphenous vein K+ channel differences limit rodent model translation; leaves open species-specific mechanisms for venous graft research.

Venous Myogenic Tone and Its Regulation Through K+Channels Depends on Chronic Intravascular Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Venous Myogenic Tone and Its Regulation Through K+Channels Depends on Chronic Intravascular Pressure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider