Key result
De-endothelialization of isolated human saphenous veins resulted in significantly lower maximal contraction with noradrenaline compared to normal endothelium-intact vessels.
Population
14 isolated ring preparations of presumably normal human saphenous veins obtained from vein grafts during…
Comparison
De-endothelialization by gentle rubbing, with… vs Paired normal saphenous vein rings
Design
Preclinical
Authors
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Suggests endothelial contracting factor in saphenous veins unlike arteries; leaves open its role in graft vasoreactivity.
Unlike in arteries, endothelium-derived relaxation does not occur in human saphenous veins, suggesting the possible existence of an endothelial-derived contracting factor.
Thulesius et al. (1988) studied Normal saphenous veins (n=14). De-endothelialization vs. Normal (endothelium-intact) paired rings was evaluated on Vasomotor response (isometric tension) to noradrenaline and acetylcholine. De-endothelialization of isolated human saphenous veins resulted in significantly lower maximal contraction with noradrenaline compared to normal endothelium-intact vessels.
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