June 1, 2000Blood

Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase–dependent pathway

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Population

Platelets from human donors

Design

Preclinical

Authors

JPJean‐Max PasquetUniversité de Bordeaux BGBarbara GrossInserm MGMarie‐Pierre GratacapUniversité Toulouse III - Paul Sabatier

Discussion

Member takes

Implication

PI 3-kinase mediates TPO priming of platelet collagen responses in animals; leaves open human translation and therapeutic targeting.

Structured PICO

Population

Platelets from human donors

Intervention

Thrombopoietin (TPO) and collagen, with or without PI 3-kinase inhibitors (wortmannin and LY294002)

Outcome

Platelet aggregation, secretion, and intracellular signaling (formation of phosphatidylinositol 3,4,5-trisphosphate, inositol phosphates, phosphatidic acid, and intracellular Ca(++))surrogate

The PI 3-kinase pathway plays a crucial role in collagen signaling and the priming action of thrombopoietin in platelets.

Cite This Study

Pasquet et al. (2000) studied this question.

synapsesocial.com/papers/6a82c5c2f5f149803a21ec2e https://doi.org/10.1182/blood.v95.11.3429

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Ask AI

Bookmark

Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase–dependent pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Thrombopoietin potentiates collagen receptor signaling in platelets through a phosphatidylinositol 3-kinase–dependent pathway

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider