Population
Single smooth muscle cells freshly isolated from guinea-pig vas deferens or urinary bladder
Comparison
Depolarization and pharmacological agents vs Baseline or control conditions
Design
Preclinical
Authors
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Local Ca2+ hot spots may initiate contraction and repolarization in smooth muscle; leaves open relevance to human vascular physiology.
Depolarization-induced Ca2+ entry in smooth muscle cells evokes Ca2+-induced Ca2+ release from subplasmalemmal stores, generating hot spots that initiate contraction and activate Ca2+-dependent K+ channels for repolarization.
Imaizumi et al. (1998) studied this question.
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