Key result
Normalization of plasma osmolality with 5% dextrose reduced the kynurenate-induced depressor response from -24 mmHg to -13 mmHg (P<0.05), indicating high osmolality increases EAA drive.
Population
Urethane-anesthetized rats (water-deprived and water-replete)
Comparison
Bilateral microinjection of kynurenate into the… vs Baseline state or alternative infusion
Design
Preclinical
Follow-up
up to 3 hours
Authors
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May link hyperosmolality to RVLM excitatory drive in rats; hypothesis-generating and leaves open relevance to human hypertension.
Absolute Event Rate: -13% vs -24%
p-value: p=<0.05
Acute and chronic increases in osmolality, rather than low blood volume, appear to increase excitatory amino acid drive of the rostral ventrolateral medulla in rats.
Brooks et al. (2004) studied Water deprivation and increased osmolality (n=17). Normalization of plasma osmolality (5% dextrose in water) vs. Normalization of blood volume (isotonic saline) was evaluated on Decrease in arterial pressure following kynurenate microinjection (p=<0.05). Normalization of plasma osmolality with 5% dextrose reduced the kynurenate-induced depressor response from -24 mmHg to -13 mmHg (P<0.05), indicating high osmolality increases EAA drive.
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