January 20, 2005AJP Regulatory Integrative and Comparative Physiology

Increased osmolality of conscious water-deprived rats supports arterial pressure and sympathetic activity via a brain action

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Population

Conscious water-deprived and water-replete rats

Comparison

Infusion of hypotonic fluid via bilateral… vs Intravenous infusion of hypotonic fluid, and…

Design

Preclinical

Authors

VBVirginia L. BrooksOregon Health & Science University YQYue QiGeneral / Preventive / Lipids TOTheresa L. O’DonaughyOregon Health & Science University

Discussion

Member takes

Implication

Supports brain osmoreceptor role in BP maintenance during dehydration; hypothesis-generating for human osmoregulatory hypertension.

Structured PICO

Population

Conscious water-deprived and water-replete rats

Intervention

Infusion of hypotonic fluid via bilateral nonoccluding intracarotid catheters

Comparator

Intravenous infusion of hypotonic fluid, and infusion in water-replete rats

Outcome

Mean arterial pressure (MAP), lumbar sympathetic nerve activity (LSNA), and heart ratesurrogate

Acute decreases in osmolality of carotid blood in water-deprived rats decreases MAP and LSNA, supporting the hypothesis that elevated osmolality acts via the brain to support blood pressure.

Cite This Study

Brooks et al. (2005) studied this question.

synapsesocial.com/papers/6a8540d5e1eabc68e29292b2 https://doi.org/10.1152/ajpregu.00638.2004

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Increased osmolality of conscious water-deprived rats supports arterial pressure and sympathetic activity via a brain action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased osmolality of conscious water-deprived rats supports arterial pressure and sympathetic activity via a brain action

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider