Population
Anesthetized rats divided into three groups: control, nephrotic syndrome, and congestive heart failure
Comparison
Reflex maneuvers including bilateral aortic… vs Control rats and baseline states
Design
Preclinical
Authors
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Central vagus stimulation fails to suppress renal sympathetic activity in nephrotic rats; leaves open central baroreflex defects as therapeutic targets in human cardiorenal syndromes.
The defect in cardiac baroreflex function in nephrotic syndrome is specific for ERSNA, central rather than peripheral, and affects the number of active renal sympathetic nerve fibers.
DiBona et al. (1997) studied this question.
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