Effect of Sodium Pentobarbital on the SA Nodal Activity of the Dog Heart in vivo

View Full Paper

Ask AI

Bookmark

Population

9 mongrel dogs of both sexes, weighing 11 to 16 kg, anesthetized with i.v. sodium pentobarbital (30 mg/kg).

Design

Preclinical

Authors

Discussion

Highlights SA nodal depression risk with pentobarbital in canine models; leaves open translation to other species or clinical anesthesia.

Population

9 mongrel dogs of both sexes, weighing 11 to 16 kg, anesthetized with i.v. sodium pentobarbital (30 mg/kg).

Intervention

Sodium pentobarbital injected directly into the sinus node artery (doses ranging from 10 μg to 10 mg).

Outcome

Chronotropic response of the SA node (heart rate changes)surrogate

Sodium pentobarbital directly depresses SA nodal pacemaker activity in the dog heart in situ, an effect partially antagonized by norepinephrine.

Chiba et al. (1972) studied this question.

View Full Paper

Ask AI

Bookmark