Key result
Pentobarbital sodium anesthesia did not decrease left ventricular contractility in dogs when serum concentrations were maintained at approximately 25 mg/l.
Why the study?
Does pentobarbital sodium anesthesia depress left ventricular contractility in dogs?
Population
13 dogs with implanted subendocardial ultrasonic crystal transducers and a high-fidelity pressure transducer…
Comparison
Pentobarbital sodium anesthesia vs Awake conditions
Design
Preclinical
Follow-up
1 hour after bolus
Authors
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Supports pentobarbital at ~25 mg/l in canine LV studies; leaves open translation to other models or conscious states.
Does pentobarbital sodium anesthesia depress left ventricular contractility in dogs?
Pentobarbital anesthesia does not depress left ventricular contractility in dogs when serum concentrations are maintained at approximately 25 mg/l.
Unruh et al. (1991) studied this question. Pentobarbital sodium (NP) anesthesia vs. Awake condition was evaluated on Left ventricular contractility (assessed by ejection fraction and end-systolic pressure-volume relationship). Pentobarbital sodium anesthesia did not decrease left ventricular contractility in dogs when serum concentrations were maintained at approximately 25 mg/l.
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