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April 1, 1971The Journal of PhysiologyOpen Access

The responses of aortic arch and right subclavian baroreceptors to changes of non‐pulsatile pressure and their modification by hypothermia

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Population

Rabbit model (in situ isolation of aortic arch and right subclavian-carotid angle)

Comparison

Changes in non-pulsatile pressure and… vs Baseline/steady-state conditions at different…

Design

Preclinical

Authors

JJJennifer E. Angell JamesSt Bartholomew's Hospital

Discussion

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Implication

Rabbit baroreceptor data extend preclinical baroreflex models; leaves open translation to human physiology during hypothermia.

Structured PICO

P
Population
Rabbit model (in situ isolation of aortic arch and right subclavian-carotid angle)
I
Intervention
Changes in non-pulsatile pressure and hypothermia during perfusion with Krebs-Henseleit solution or blood
C
Comparator
Baseline/steady-state conditions at different pressures and temperatures
O
Outcome
Frequency of baroreceptor impulse activitysurrogate

This preclinical study characterizes the physiological responses of aortic arch and right subclavian baroreceptors to pressure changes and hypothermia in a rabbit model.

Cite This Study

Jennifer E. Angell James (1971) studied this question.

synapsesocial.com/papers/6a82df44ac779081c023bb3ehttps://doi.org/10.1113/jphysiol.1971.sp009428
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effects of changes of extramural, ‘intrathoracic’, pressure on aortic arch baroreceptors1971 · 81 citations
  2. 2The effects of altering mean pressure, pulse pressure and pulse frequency on the impulse activity in baroreceptor fibres from the aortic arch and right subclavian artery in the rabbit1971 · 109 citations
  3. 3Reflex Control of Blood Pressure by the Right Subclavian Baroreceptor in Experimental Renal Hypertension of Rabbit1966 · 9 citations
  4. 4Relationship between Aortic Diameter and Aortic Baroreceptor Activity in Normal and Hypertensive Rabbits1969 · 46 citations
  5. 5The effects of haemorrhage in the unanaesthetized rabbit1967 · 50 citations