Key result
Rheumatic heart disease was associated with significantly higher plasma BNP concentrations compared to healthy control subjects (232±294 vs. 14±12 pg/ml, p<0.0001).
Why the study?
Are plasma BNP levels elevated in patients with rheumatic heart disease compared to healthy controls, and do they correlate with disease severity?
Case-Control (n=112)
Are plasma BNP levels elevated in patients with rheumatic heart disease compared to healthy controls, and do they correlate with disease severity?
Absolute Event Rate: 232% vs 14%
p-value: p=<0.0001
Plasma BNP levels are significantly elevated in patients with rheumatic heart disease and correlate with clinical and echocardiographic markers of disease severity.
May support BNP assessment in rheumatic heart disease; hypothesis-generating for severity correlation, should not yet change practice.
BACKGROUND: Brain natriuretic peptide (BNP) is a cardiac hormone secreted from the ventricular myocardium as a response to ventricular volume expansion and pressure overload. Rheumatic heart disease (RHD) is still an important cause of heart failure in developing countries. AIMS: To measure BNP levels in patients with RHD and to determine whether BNP concentrations correlate with clinical and echocardiographic findings. METHODS: Eighty-eight patients with rheumatic valve disease and 24 age- and sex-matched healthy subjects were entered in the study. BNP was measured using the Triage B-Type Natriuretic Peptide test (Biosite Diagnostics, San Diego, CA). Transthoracic echocardiography was performed in all patients to assess the severity of the valve disease and for the measurement of pulmonary artery pressure. RESULTS: The plasma concentrations of BNP were significantly higher in patients with rheumatic heart disease than in control subjects (232+/-294 vs. 14+/-12 pg/ml, p<0.0001). The plasma BNP level was significantly higher in NYHA class III+IV than in class II (463+/-399 vs. 192+/-243 pg/ml, p<0.0001) and in NYHA class II than in class I (192+/-243 vs. 112+/-135 pg/ml, p<0.001). The independent determinants of higher BNP levels were NYHA functional class and systolic pulmonary artery pressure in multivariate analysis. CONCLUSION: We found increased plasma BNP levels in patients with rheumatic heart disease compared with healthy subjects.
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Gölbaþý et al. (2004) conducted a case-control in Rheumatic heart disease (n=112). Rheumatic heart disease vs. Healthy subjects was evaluated on Plasma BNP levels (p=<0.0001). Rheumatic heart disease was associated with significantly higher plasma BNP concentrations compared to healthy control subjects (232±294 vs. 14±12 pg/ml, p<0.0001).
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