Key result
Acute captopril infusion rapidly increased proximal tubule flow and diuresis (from 2.1 to 3.7 mg/min) and provoked the redistribution of transporters out of apical membranes.
Why the study?
Does acute captopril infusion alter proximal tubule sodium transport and protein distribution independently of blood pressure or GFR changes?
Population
Preclinical model (in vivo)
Comparison
Acute captopril infusion vs Baseline (pre-infusion)
Design
Preclinical
Follow-up
20 minutes
Authors
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Suggests proximal tubule effects contribute to ACEI natriuresis; hypothesis-generating in this animal model, leaves open human translation.
Does acute captopril infusion alter proximal tubule sodium transport and protein distribution independently of blood pressure or GFR changes?
Absolute Event Rate: 3.7% vs 2.1%
Captopril rapidly depresses proximal tubule reabsorption and provokes the redistribution of transporters independently of changes in GFR or blood pressure, which may contribute to the blood pressure-lowering effect of ACE inhibitors.
Leong et al. (2005) studied this question. Captopril vs. Baseline was evaluated on Proximal tubule flow and diuresis. Acute captopril infusion rapidly increased proximal tubule flow and diuresis (from 2.1 to 3.7 mg/min) and provoked the redistribution of transporters out of apical membranes.
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