Key result
Mean platelet volume was significantly higher in patients with acute coronary syndrome compared to controls (12.48 vs 10.45 fL) and demonstrated a sensitivity of 90.6% and specificity of 49.4% for early detection.
Why the study?
Does elevated mean platelet volume improve the early detection of acute coronary syndrome in patients presenting with suspected ACS?
Population
142 adult patients with clinically suspected acute coronary syndrome attending cardiac emergency, including…
Comparison
Measurement of mean platelet volume and platelet… vs Patients without acute coronary syndrome.
Design
Case-control
Follow-up
5 days
Authors
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May aid ACS detection when other biomarkers are negative; leaves open prospective validation before clinical adoption.
Case-Control (n=142)
Yes
Does elevated mean platelet volume improve the early detection of acute coronary syndrome in patients presenting with suspected ACS?
Absolute Event Rate: 12.48% vs 10.45%
p-value: p=0.001
Elevated mean platelet volume is a sensitive biomarker that may aid in the early detection and risk stratification of acute coronary syndrome when other cardiac biomarkers are negative.
Pervin et al. (2014) conducted a case-control in Acute coronary syndrome (n=142). Elevated mean platelet volume vs. Non-ACS controls was evaluated on Mean platelet volume (fL) on admission (p=0.001). Mean platelet volume was significantly higher in patients with acute coronary syndrome compared to controls (12.48 vs 10.45 fL) and demonstrated a sensitivity of 90.6% and specificity of 49.4% for early detection.
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