Why the study?
Does 1-hydrazinophthalazine affect pulmonary and systemic arterial pressures in patients with mitral stenosis?
Does 1-hydrazinophthalazine affect pulmonary and systemic arterial pressures in patients with mitral stenosis?
1-hydrazinophthalazine elevates pulmonary arterial pressure while reducing systemic arterial pressure in patients with mitral stenosis, highlighting a critical hemodynamic effect when treating hypertension in this population.
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May raise pulmonary pressure in mitral stenosis; leaves open hydralazine safety in this population.
During the investigation of the effects of hypotensive agents on the pulmonary circulation in mitral stenosis, an unexpected result was observed following the administration of 1-hydrazinophthalazine (apresoline). It was found that in patients with mitral stenosis, this drug caused elevation of the pulmonary arterial pressure, while reducing the systemic arterial pressure. This effect of l-hydrazinophthalazine may be of considerable importance in the treatment of hypertension asso- ciated with mitral disease.
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Aitchison et al. (1955) studied this question.
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