Studies on the Renal Circulation and Renal Function in Mitral Valvular Disease

Lars Werkö; Edvardas Varnauskas; J. Ek; Bengt Thomasson; Jonas Bergström; Harald Eliasch

doi:10.1161/01.cir.9.5.700

May 1, 1954Circulation

Studies on the Renal Circulation and Renal Function in Mitral Valvular Disease

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Why the study?

Does hydralazine improve renal blood flow in patients with mitral stenosis?

Key Points

To evaluate the nature of impaired renal circulation and depressed kidney function in mitral stenosis and assess whether these vascular changes can be reversed using Apresoline.
Administered Apresoline during cardiac catheterization to 12 patients presenting with mitral stenosis of varying severity.
Assessed changes in renal blood flow alongside systemic arterial blood pressure after drug administration.
Apresoline administration increased renal blood flow while concurrently lowering systemic arterial blood pressure.
The hemodynamic changes confirmed that renal circulatory impairment in mitral stenosis is reversible.
Renal blood flow enhancement occurred independently of the drug's hypotensive effect on arterial blood pressure.

Structured PICO

Does hydralazine improve renal blood flow in patients with mitral stenosis?

P

Population

12 patients with mitral stenosis of varying severity, lowered renal function, and reduced renal circulation

I

Intervention

Hydralazine (Apresoline) administered during heart catheterization

O

Outcome

Renal blood flow and arterial blood pressuresurrogate

Hydralazine acutely improves renal blood flow in patients with mitral stenosis, indicating that the associated renal hemodynamic changes are reversible.

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Implication

Hydralazine may reverse renal changes in mitral stenosis; hypothesis-generating and should not change practice.

Abstract

In a study of the nature of the renal changes in patients with mitral stenosis, lowered renal function and reduced renal circulation the effect of Apresoline, given during heart catheterization to 12 patients with mitral stenosis of varying severity, was studied. The drug was found to increase renal blood flow (and decrease arterial blood pressure), showing that the renal changes in mitral stenosis are reversible. The two effects of Apresoline were shown to be independent of each other.

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Cite This Study

Werkö et al. (1954) studied this question.

synapsesocial.com/papers/6a7ce965413d908bbb8d1aa4 https://doi.org/10.1161/01.cir.9.5.700

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Studies on the Renal Circulation and Renal Function in Mitral Valvular Disease

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Studies on the Renal Circulation and Renal Function in Mitral Valvular Disease

Key Points

Structured PICO

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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