July 1, 1995AJP Heart and Circulatory Physiology
Modulation of cardiac Na(+)-K+ pump current: role of protein and nonprotein sulfhydryl redox status
Population
Guinea pig ventricular myocytes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports sulfhydryl oxidation in reperfusion pump stress; leaves open human relevance from this animal model.
Structured PICO
P
Population
Guinea pig ventricular myocytes
I
Intervention
p-chloromercuriphenylsulfonic acid (pCMPSA) applied intracellularly or extracellularly, and diethyl maleate (860 mg/kg i.p.)
O
Outcome
Na(+)-K+ pump current (i.p.)surrogate
Protein sulfhydryl oxidation and glutathione depletion may account for a depression in Na(+)-K+ pump activity during reperfusion-induced oxidant stress.
Cite This Study
Haddock et al. (1995) studied this question.