Oxidant stress inhibits Na-Ca-exchange current in cardiac myocytes: mediation by sulfhydryl groups?

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Population

Guinea pig ventricular myocytes

Design

Preclinical

Authors

Discussion

Oxidant stress may inhibit NCX current in myocytes; hypothesis-generating for its role in cardiac disease and requires in vivo validation.

Population

Guinea pig ventricular myocytes

Intervention

Oxidant stress (xanthine oxidase plus hypoxanthine or photoactivation of rose bengal) or diamide

Outcome

Na(+)-Ca(2+)-exchange current (Ni(2+)-sensitive and extracellular calcium concentration-activated current)surrogate

Oxidant stress decreases the Na(+)-Ca2+ exchanger current in cardiac myocytes, an effect likely mediated by sulfhydryl groups.

Coetzee et al. (1994) studied this question.

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Oxidant stress may inhibit NCX current in myocytes; hypothesis-generating for its role in cardiac disease and requires in vivo validation.