Key result
Oxidant stress depolarizes ventricular myocytes by decreasing inward-rectifier potassium conductance ~38%.
Why the study?
The ionic basis of electrophysiological changes induced by oxidant stress in isolated ventricular myocytes was not fully understood.
Absolute Event Rate: 25% vs 40%
No takes yet. Share an insight, caveat, or question.
May promote arrhythmogenesis under oxidative stress; leaves open relevance to intact hearts or clinical arrhythmias.
Matsuura et al. (1991) studied this question. Oxidant stress (photoactivation of rose bengal) vs. Baseline (resting membrane potential) was evaluated on Slope conductance of the inward-rectifier potassium channel. Oxidant stress depolarized isolated ventricular myocytes by decreasing inward-rectifier potassium channel slope conductance from 40 to 25 nS and activating calcium-activated membrane conductance.
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