Key result
Adding hydrochlorothiazide to valsartan 160 mg/day reduced blood pressure (-10.5/-6.9 mm Hg, P<0.01) in hypertensive African Americans more effectively than doubling valsartan or adding benazepril.
Why the study?
Does adding hydrochlorothiazide or benazepril, or doubling the dose of valsartan, improve blood pressure reduction in hypertensive African Americans on a high salt diet?
Population
88 hypertensive African Americans
Comparison
Valsartan 160 mg/day plus hydrochlorothiazide… vs The three randomized therapeutic regimens were…
Design
RCT, randomized, open label
Follow-up
12 weeks total (6 weeks randomized phase)
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Supports adding hydrochlorothiazide to valsartan over dose doubling or benazepril in African American hypertensives; extends combination therapy evidence for this population.
RCT (n=88)
Open-label
Randomized
Does adding hydrochlorothiazide or benazepril, or doubling the dose of valsartan, improve blood pressure reduction in hypertensive African Americans on a high salt diet?
p-value: p=<.01
In hypertensive African Americans, adding a low dose of hydrochlorothiazide to valsartan is more effective at lowering blood pressure than doubling the valsartan dose or adding an ACE inhibitor.
A 2001 study conducted an RCT in Hypertension (n=88). Valsartan plus hydrochlorothiazide vs. Valsartan 320 mg/day or Valsartan 160 mg/day + benazepril 20 mg/day was evaluated on Incremental reduction in systolic and diastolic blood pressure (p=<.01). Adding hydrochlorothiazide to valsartan 160 mg/day reduced blood pressure (-10.5/-6.9 mm Hg, P<0.01) in hypertensive African Americans more effectively than doubling valsartan or adding benazepril.
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