Population
Drosophila females with null mutant background for the spaghetti squash (sqh) gene during oocyte development
Comparison
Transgenes with altered phosphorylation sites vs sqh null allele and wild type
Design
Preclinical
Authors
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Drosophila evidence supports serine-21 primacy in nonmuscle myosin II; extends mechanistic data but leaves open mammalian cardiac translation.
In vivo genetic evidence in Drosophila demonstrates that phosphorylation at serine-21 is critical for regulatory myosin light chain function in activating nonmuscle myosin II.
Jordan et al. (1997) studied this question.
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