Why the study?
Does ET(A) or ET(B) receptor antagonism improve renal reperfusion and survival in Lewis rats undergoing renal transplantation after cold ischaemia?
Population
Lewis rats undergoing left renal transplantation following 2 h or 16 h cold ischaemia
Comparison
ET receptor antagonist or ET receptor antagonist… vs No treatment
Design
Preclinical
Follow-up
15 days
Authors
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ET(A) antagonism in preservation solution is hypothesis-generating in rat renal transplant models; leaves open translation to human graft preservation.
Does ET(A) or ET(B) receptor antagonism improve renal reperfusion and survival in Lewis rats undergoing renal transplantation after cold ischaemia?
ET(A) receptor antagonism in preservation solution improves renal reperfusion and survival after prolonged cold ischaemia in a rat renal transplant model.
Hammad et al. (2000) studied this question.
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