Why the study?
Does the endothelin antagonist BQ-123 improve renal function in an isolated perfused rat kidney model of ischemic acute renal failure?
Population
Isolated perfused rat kidney model
Comparison
Endothelin antagonist BQ-123 given before the… vs No treatment (control) or endothelin alone
Design
Preclinical
Follow-up
60 min of arterial clamping followed by reperfusion
Authors
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Pre-ischemic BQ-123 may protect renal function in rat ischemia; leaves open whether timing-dependent endothelin blockade translates to clinical acute kidney injury.
Does the endothelin antagonist BQ-123 improve renal function in an isolated perfused rat kidney model of ischemic acute renal failure?
The endothelin-receptor antagonist BQ-123 protects against ischemic acute renal failure in a rat model only when administered prior to the ischemic insult.
Chan et al. (1994) studied this question.
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