BQ-123, a specific endothelin (ETA) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation

View Full Paper

Ask AI

Bookmark

Why the study?

Does BQ-123 prevent ischemia-reperfusion injury in a rat model of kidney transplantation?

Structured PICO

Does BQ-123 prevent ischemia-reperfusion injury in a rat model of kidney transplantation?

Population

Rat model of kidney transplantation (Sprague-Dawley recipients, white Wistar albino donors)

Intervention

Allografts flushed with 20 micrograms BQ-123 containing cold Ringer's lactate before transplantation

Comparator

Sham nephrectomy, autotransplantation, and allotransplantation without BQ-123

Outcome

Ischemia-reperfusion injury assessed by ET-1,2 plasma concentrations, lipid peroxidation, protein oxidation, and histopathologysurrogate

BQ-123, an ETA receptor antagonist, prevents ischemia-reperfusion injury in a rat model of kidney transplantation.

No takes yet. Share an insight, caveat, or question.

Attenuates oxidative stress in rat kidney transplant IRI; leaves open whether ETA antagonism improves clinical outcomes.

B�y�kgebiz et al. (1996) studied this question.

View Full Paper

Ask AI

Bookmark