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May 1, 1996Transplant International

BQ-123, a specific endothelin (ETA) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation

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Population

Rat model of kidney transplantation (Sprague-Dawley recipients, white Wistar albino donors for allografts)

Comparison

Allografts flushed with 20 µg BQ-123 containing… vs Sham nephrectomy, autotransplantation, and…

Design

Preclinical

Follow-up

120 min of reperfusion after 40 min of cold ischemia

Authors

OBOğuzhan BüyükgebizKocaeli ÜniversitesiAAA. Özdemir AktanÜsküdar UniversityGHGonca HaklarMarmara University

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Implication

Hypothesis-generating for ETA antagonism in kidney transplant IRI; clinical translation studies required before any practice consideration.

Structured PICO

P
Population
Rat model of kidney transplantation (Sprague-Dawley recipients, white Wistar albino donors for allografts)
I
Intervention
Allografts flushed with 20 µg BQ-123 containing cold Ringer's lactate before transplantation
C
Comparator
Sham nephrectomy, autotransplantation, and allotransplantation without BQ-123
O
Outcome
Reperfusion injury assessed by ET-1,2 plasma concentrations, lipid peroxidation products, protein oxidation parameters, and histopathologic examinationsurrogate

BQ-123, an ETA receptor antagonist, prevents ischemia-reperfusion injury in a rat model of kidney transplantation by reducing oxidative stress and tissue injury.

Cite This Study

Büyükgebiz et al. (1996) studied this question.

synapsesocial.com/papers/6a8162c9267334e2baf09752https://doi.org/10.1111/j.1432-2277.1996.tb00880.x
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