Population
Conscious Long Evans rats, chronically instrumented for the continuous recording of heart rate, systemic…
Comparison
Phosphoramidon administered with human… vs Human proendothelin [1-38] in the absence of…
Design
Preclinical
Authors
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Mediates most proendothelin effects via phosphoramidon-sensitive conversion in animals; extends mechanistic data but leaves human translation open.
The findings suggest that the cardiovascular effects of human proendothelin [1-38] are due to its local conversion to endothelin-1 by phosphoramidon-sensitive enzyme systems in vivo.
Gardiner et al. (1991) studied this question.
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