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Observational BP reductions post-adrenalectomy in hypertension warrant caution; leaves open causal role in essential hypertension.
The profound influence exerted by the adrenal cortex on vascular activity has been abundantly demonstrated in laboratory animals, and there are good clinical grounds for inferring a similar relationship in man. In hypertensive patients who subsequently develop Addi- son's disease or who are treated by bilateral adrenalec- tomy a fall in blood pressure has been noted (Perera,
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Ginsburg et al. (1958) studied this question.
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