Glycemic variability in continuous glucose monitoring is inversely associated with baroreflex sensitivity in type 2 diabetes: a preliminary report

94 hospitalized patients with type 2 diabetes (mean age 62.1, 70% male) in Japan. Exclusions: taking non-dihydropyridine calcium channel blockers, digitalis, or antipsychotics; arrhythmia, severe renal dysfunction (serum Cr ≥ 2.5 mg/dL), severe liver dysfunction, severe infection, severe trauma, pre- and post-operation, diabetic ketosis, diabetic coma, insulin-dependent diabetes mellitus, malignancy, myocardial infarction, heart failure, cerebral infarction within a half year, pregnancy, or heavy alcohol consumption.

Continuous glucose monitoring (CGM) for 48 hours to assess glycemic variability parameters including standard deviation (SD), glucose coefficient of variation (CV), and mean amplitude of glycemic excursions (MAGE).

Relationship between glycemic variability (CGM-SD, CGM-CV, MAGE) and baroreflex sensitivity (BRS) measured on the first day of hospitalization.surrogate