March 1, 2010SLEEPOpen Access

Dysregulation of Heart Rhythm During Sleep in Leptin-Deficient Obese Mice

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Population

18 male mice

Comparison

Congenital leptin deficiency (ob/ob mouse model) vs Lean wild-type (+/+) mice

Design

Preclinical

Authors

ASAlessandro SilvaniOspedale "Santa Maria delle Croci" di Ravenna SBStefano BastianiniUniversity of Bologna CBChiara BerteottiUniversity of Bologna

Discussion

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Implication

No clinical change from mouse data; extends models for studying obesity-related autonomic dysregulation during sleep.

Structured PICO

Population

18 male mice (7 ob/ob with morbid obesity caused by congenital leptin deficiency and 11 lean wild-type +/+ mice)

Intervention

Congenital leptin deficiency (ob/ob mouse model)

Comparator

Lean wild-type (+/+) mice

Outcome

Indexes of cardiac autonomic control (variability of heart period, cardiac baroreflex sensitivity, vagal modulation) during wakefulness, non-rapid eye movement sleep (NREMS), and rapid eye movement sleep (REMS)surrogate

Leptin-deficient obese mice exhibit dysregulation of cardiac autonomic control during sleep, providing a useful model to study sleep-related autonomic derangements in obesity.

Cite This Study

Silvani et al. (2010) studied this question.

synapsesocial.com/papers/6a832b3f88eff2bd7befebf7 https://doi.org/10.1093/sleep/33.3.355

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Dysregulation of Heart Rhythm During Sleep in Leptin-Deficient Obese Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dysregulation of Heart Rhythm During Sleep in Leptin-Deficient Obese Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider