Defibrillating shocks delivered to the heart impair efferent sympathetic responsiveness.
Why the study?
Do defibrillating shocks delivered directly to the heart impair efferent sympathetic responsiveness in an open-chest dog model?
Population
Anesthetized open-chest dogs
Comparison
Low-, medium-, or high- energy truncated… vs Before shock delivery or shocks delivered over…
Design
Preclinical
Follow-up
Up to 3 hours
Authors
Discussion
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Member takes
Implication
May affect post-shock hemodynamics in animal models; leaves open relevance to human defibrillation.
Structured PICO
Do defibrillating shocks delivered directly to the heart impair efferent sympathetic responsiveness in an open-chest dog model?
P
Population
Anesthetized open-chest dogs
I
Intervention
Low- (≤ 1 J), medium- (6 to 16 J), or high- (30 to 35 J) energy truncated monophasic exponential shocks delivered over implantable patches sutured inside the pericardium
C
Comparator
Before shock delivery (baseline) or shocks delivered over patches sutured outside the pericardium
O
Outcome
Shortening of ventricular effective refractory period (ERP) produced by bilateral ansae subclaviae stimulation (SS)surrogate
DC shocks >10 J delivered directly to the epicardium attenuate efferent sympathetic neural function, which may affect electrophysiological and hemodynamic responses after cardioversion-defibrillation.
Cite This Study
Ito et al. (1993) studied this question.