Why the study?
Does the combination of arterial blood pressure and heart rate determine ischemic myocardial dysfunction in a canine model of coronary stenosis?
Population
Canine model of coronary stenosis
Comparison
20 combinations of mean arterial pressure and… vs Unstenosed control
Design
Preclinical
Authors
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Caution against clinical use of pressure-rate ratio targets; leaves open translation from canine stenosis models to human practice.
Does the combination of arterial blood pressure and heart rate determine ischemic myocardial dysfunction in a canine model of coronary stenosis?
In a canine model of coronary stenosis, ischemic myocardial dysfunction depends on the interaction between blood pressure and heart rate, with ischemia absent when the pressure-rate ratio exceeds one.
Charles W. Buffington (1985) studied this question.
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