Relationship between 25-hydroxyvitamin D Level and Idiopathic Premature ventricular Complexes

Introduction: Idiopathic premature ventricular contractions (PVCs) are the most prevalant ventricular arrhythmias. Vitamin D and intact parathyroid hormone (iPTH) play role in cardiovascular system, but their affect on premature ventricular complex (PVC) triggering is still uncertain. We investigated the effect of serum 25-hydroxyvitamin D (25[OH]D) and iPTH on PVC burden in our patients. Method: In this study, a total of 128 patients, who underwent electrocardiography (ECG), 24-hour Holter recordings and transthoracic echocardiographic examination as a study protocol were enrolled. In addition, serum 25(OH)D, iPTH levels were measured. The patients were divided into two groups as 64 of them with PVC and 64 of them as normal healthy controls. Results: A 64 patients with frequent PVCs (median age 41 [16-84], male 33/64) and Sixty-four controls (median age 38 [19-72], male 34/64), were included in the study. Parathyroid hormone levels were higher (51.70 [18.35-139.30] vs 73.60 [40.40-139.30], p<0.001) and 25(OH)D levels were lower (27.846.79 vs. 17.086.36, p<0.001) in patients compared to controls. There were no significant differences between the study groups in terms of phosphorus and other blood chemistry parameters, whereas serum calcium levels were lower in the PVC group. Discussion and Conclusion: High iPTH levels or lower 25-hydroxyvitamin D levels that might be implicated in the pathophysiology of PVC occurrence; even at the normally accepted reference range, may affect ventricular arrhythmias.